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Trans ‐Platinum/Thiazole Complex Interferes with Sp1 Zinc‐Finger Protein
Author(s) -
Chen Siming,
Xu Dechen,
Jiang Huan,
Xi Zhaoyong,
Zhu Pingping,
Liu Yangzhong
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206596
Subject(s) - zinc finger , thiazole , cytoplasm , in vitro , platinum , reactivity (psychology) , chemistry , nucleus , transcription factor , dna , transcription (linguistics) , computational biology , microbiology and biotechnology , information retrieval , biochemistry , biology , combinatorial chemistry , stereochemistry , gene , computer science , medicine , philosophy , catalysis , linguistics , alternative medicine , pathology
No trafficking : The antitumor‐active trans ‐platinum/thiazole complex trans ‐PtTz demonstrated high reactivity to the transcription factor Sp1, which is overexpressed in tumor cells. The binding of trans ‐PtTz disrupts the DNA interaction with Sp1 in vitro and prevents the protein trafficking from the cytoplasm into the nucleus (see picture).