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The Total Synthesis of Corallopyronin A and Myxopyronin B
Author(s) -
Rentsch Andreas,
Kalesse Markus
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206560
Subject(s) - total synthesis , chemistry , rna polymerase , content (measure theory) , computer science , computational biology , world wide web , information retrieval , stereochemistry , biology , rna , biochemistry , gene , mathematics , mathematical analysis
Leading the way : The synthesis of natural products with new biological targets is one of the driving forces for the development of new antibiotics. The synthesis of the two secondary metabolites corallopyronin and myxopyronin (see picture) have been achieved, which are prominent leads for the inhibition of bacterial RNA polymerase.