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The G‐Triplex DNA
Author(s) -
Limongelli Vittorio,
De Tito Stefano,
Cerofolini Linda,
Fragai Marco,
Pagano Bruno,
Trotta Roberta,
Cosconati Sandro,
Marinelli Luciana,
Novellino Ettore,
Bertini Ivano,
Randazzo Antonio,
Luchinat Claudio,
Parrinello Michele
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206522
Subject(s) - metadynamics , aptamer , oligonucleotide , g quadruplex , twist , dna , chemistry , crystallography , biophysics , molecular dynamics , computational chemistry , biochemistry , biology , microbiology and biotechnology , mathematics , geometry
Triplex with a twist : Through metadynamics calculations, the thrombin binding aptamer (TBA) has been shown to adopt a stable G‐triplex structural motif, in addition to the usual G‐quadruplex (see scheme). An 11‐mer oligonucleotide was also shown to form a stable G‐triplex, whose structural and thermodynamic properties have been characterized.