The G‐Triplex DNA | Zendy

Limongelli Vittorio | Zendy; De Tito Stefano | Zendy; Cerofolini Linda | Zendy; Fragai Marco | Zendy; Pagano Bruno | Zendy; Trotta Roberta | Zendy; Cosconati Sandro | Zendy; Marinelli Luciana | Zendy; Novellino Ettore | Zendy; Bertini Ivano | Zendy; Randazzo Antonio | Zendy; Luchinat Claudio | Zendy; Parrinello Michele | Zendy

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The G‐Triplex DNA

Author(s) -

Limongelli Vittorio,

De Tito Stefano,

Cerofolini Linda,

Fragai Marco,

Pagano Bruno,

Trotta Roberta,

Cosconati Sandro,

Marinelli Luciana,

Novellino Ettore,

Bertini Ivano,

Randazzo Antonio,

Luchinat Claudio,

Parrinello Michele

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201206522

Subject(s) - metadynamics , aptamer , oligonucleotide , g quadruplex , twist , dna , chemistry , crystallography , biophysics , molecular dynamics , computational chemistry , biochemistry , biology , microbiology and biotechnology , mathematics , geometry

Triplex with a twist : Through metadynamics calculations, the thrombin binding aptamer (TBA) has been shown to adopt a stable G‐triplex structural motif, in addition to the usual G‐quadruplex (see scheme). An 11‐mer oligonucleotide was also shown to form a stable G‐triplex, whose structural and thermodynamic properties have been characterized.

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