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Oligothiophene Amphiphiles as Planarizable and Polarizable Fluorescent Membrane Probes
Author(s) -
Fin Andrea,
Vargas Jentzsch Andreas,
Sakai Naomi,
Matile Stefan
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206446
Subject(s) - fluorophore , fluorescence , amphiphile , vesicle , membrane , fluorescence anisotropy , membrane fluidity , chemistry , polarizability , biophysics , nanotechnology , biology , biochemistry , materials science , organic chemistry , optics , physics , molecule , polymer , copolymer
Lessons from lobster coloration and the chemistry of vision suggested an approach to responsive fluorescent probes that can sense membrane potential, fluidity, and tension. Fluorophore deplanarization by lateral crowding along the scaffold (red circles) and fluorophore polarization by terminal donors (D), acceptors (A), and charges (+) are coupled to provide such membrane probes, as studies with unilamellar vesicles of phospholipids (DOPC, DPPC) show.
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