Enzyme‐Responsive Controlled Release of Covalently Bound Prodrug from Functional Mesoporous Silica Nanospheres | Zendy

Popat Amirali | Zendy; Ross Benjamin P. | Zendy; Liu Jian | Zendy; Jambhrunkar Siddharth | Zendy; Kleitz Freddy | Zendy; Qiao Shi Zhang | Zendy

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Enzyme‐Responsive Controlled Release of Covalently Bound Prodrug from Functional Mesoporous Silica Nanospheres

Author(s) -

Popat Amirali,

Ross Benjamin P.,

Liu Jian,

Jambhrunkar Siddharth,

Kleitz Freddy,

Qiao Shi Zhang

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201206416

Subject(s) - prodrug , sulfapyridine , nanocarriers , mesoporous silica , chemistry , covalent bond , enzyme , combinatorial chemistry , mesoporous material , biochemistry , organic chemistry , drug delivery , catalysis

I want to break free : Mesoporous silica nanoparticles are functionalized with sulfasalazine (SZ; see scheme), a prodrug of 5‐aminosalicylic acid (5‐ASA) and sulfapyridine, to generate enzyme‐responsive nanocarriers. In the presence of the colon‐specific enzyme azo‐reductase (orange), 5‐ASA and sulfapyridine are efficiently released.

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