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Double‐Effector Nanoparticles: A Synergistic Approach to Apoptotic Hyperthermia
Author(s) -
Yoo Dongwon,
Jeong Heeyeong,
Preihs Christian,
Choi Jinsil,
Shin TaeHyun,
Sessler Jonathan L.,
Cheon Jinwoo
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206400
Subject(s) - effector , apoptosis , hyperthermia , reactive oxygen species , nanoparticle , programmed cell death , chemistry , cancer research , apoptotic cell death , microbiology and biotechnology , nanotechnology , biology , medicine , biochemistry , materials science
Highly efficient apoptotic hyperthermia is achieved using a double‐effector nanoparticle that can generate reactive oxygen species (ROS) and heat. ROS render cancer cells more susceptible to subsequent heat treatment, which remarkably increases the degree of apoptotic cell death. Xenograft tumors (100 mm 3 ) in mice are completely eliminated within 8 days after a single mild magnetic hyperthermia treatment at 43 °C for 30 min.