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Self‐Healing Microencapsulation of Biomacromolecules without Organic Solvents
Author(s) -
Reinhold Samuel E.,
Desai KashappaGoud H.,
Zhang Li,
Olsen Karl F.,
Schwendeman Steven P.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206387
Subject(s) - archaeology , history
Capture and seal off all exits! Biomacromolecules are routinely microcapsulated in poly(lactic‐ co ‐glycolic acid) (PLGA) in multiple complex steps that are deleterious to the biomacromolecule. In contrast, PLGA encapsulation based on self‐healing (see picture) shows high efficiency without protein damage and enables the stabilization and slow release of proteins.