Nanoparticles and Peptides: A Fruitful Liaison for Biomimetic Catalysis | Zendy

Stodulski Maciej | Zendy; Gulder Tanja | Zendy

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Nanoparticles and Peptides: A Fruitful Liaison for Biomimetic Catalysis

Author(s) -

Stodulski Maciej,

Gulder Tanja

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201206373

Subject(s) - peptide , catalysis , nanoparticle , substrate (aquarium) , hydrolysis , chemistry , nanotechnology , substrate specificity , combinatorial chemistry , enzyme , organic chemistry , materials science , biochemistry , biology , ecology

Inspired by nature : Self‐assembled peptide nanoparticles have been designed that accelerate ester hydrolysis (see picture; Cbz=carbobenzyloxy, NP= p ‐NO 2 ‐C 6 H 4 ). The concerted interplay of the multivalent surface with the catalytically active peptide and the substrate at the same time combines several aspects decisive for the catalyst's efficiency, a property characteristic of enzymes.

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