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Nanoparticles and Peptides: A Fruitful Liaison for Biomimetic Catalysis
Author(s) -
Stodulski Maciej,
Gulder Tanja
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206373
Subject(s) - peptide , catalysis , nanoparticle , substrate (aquarium) , hydrolysis , chemistry , nanotechnology , substrate specificity , combinatorial chemistry , enzyme , organic chemistry , materials science , biochemistry , biology , ecology
Inspired by nature : Self‐assembled peptide nanoparticles have been designed that accelerate ester hydrolysis (see picture; Cbz=carbobenzyloxy, NP= p ‐NO 2 ‐C 6 H 4 ). The concerted interplay of the multivalent surface with the catalytically active peptide and the substrate at the same time combines several aspects decisive for the catalyst's efficiency, a property characteristic of enzymes.