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Functionalizing αvβ3‐ or α5β1‐Selective Integrin Antagonists for Surface Coating: A Method To Discriminate Integrin Subtypes In Vitro
Author(s) -
Rechenmacher Florian,
Neubauer Stefanie,
Polleux Julien,
MasMoruno Carlos,
De Simone Mariarosaria,
CavalcantiAdam Elisabetta Ada,
Spatz Joachim P.,
Fässler Reinhard,
Kessler Horst
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206370
Subject(s) - coating , integrin , in vitro , adhesion , computational biology , computer science , chemistry , nanotechnology , cell , materials science , biochemistry , biology , organic chemistry
Stuck with the right choice : αvβ3‐ or α5β1‐selective integrin ligands were functionalized for surface coating without losing activity and selectivity. The coating of nanostructured gold surfaces with these compounds stimulated subtype‐selective cell adhesion of genetically modified αvβ3‐ or α5β1‐expressing fibroblasts in vitro.