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The Thiolate‐Catalyzed Intermolecular Crossed Tishchenko Reaction: Highly Chemoselective Coupling of Two Different Aromatic Aldehydes
Author(s) -
Curran Simon P.,
Con Stephen J.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206343
Subject(s) - disproportionation , catalysis , intermolecular force , chemistry , scope (computer science) , functional group , combinatorial chemistry , organic chemistry , molecule , computer science , polymer , programming language
Crossed products : Ortho ‐substituted benzaldehydes react with other aromatic aldehydes in a highly selective, atom‐economical Tishchenko disproportionation (see scheme) in the presence of a readily prepared, inexpensive thiolate‐based catalyst. The methodology is of exceptionally wide scope and exhibits a high functional‐group tolerance.