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Activation of a C(sp 3 )H Bond by a Transient σ‐Alkylpalladium(II) Complex: Synthesis of Spirooxindoles Through a Palladium‐Catalyzed Domino Carbopalladation/C(sp 3 )C(sp 3 ) Bond‐Forming Process
Author(s) -
Piou Tiffany,
Neuville Luc,
Zhu Jieping
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206267
Subject(s) - humanities , art
Heck shortens the distance : A method for the palladium‐catalyzed activation of a C(sp 3 )H bond by a σ‐alkyl Pd II complex generated in situ from a remote arylhalide function has been developed. This approach allows a novel domino carbopalladation/C(sp 3 )C(sp 3 ) bond‐forming process to provide rapid access to biologically relevant spirooxindoles.