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Ruthenium‐Catalyzed ortho ‐Alkylation of Phenols with Alcohols by Dehydrative Coupling
Author(s) -
Walton James W.,
Williams Jonathan M. J.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206246
Subject(s) - ruthenium , alkylation , phenols , catalysis , chemistry , organic chemistry , coupling (piping) , combinatorial chemistry , medicinal chemistry , materials science , metallurgy
Only water : Phenols have been shown to undergo a ruthenium‐catalyzed ortho ‐alkylation reaction (see scheme; Cy=cyclohexyl). Unactivated alcohols are used as the alkylating agents and water is the only by‐product that is generated, making this transformation more atom‐economical and greener than traditional methods.