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Synthesis of Aromatic α‐Aminoesters: Palladium‐Catalyzed Long‐Range Arylation of Primary C sp 3 H Bonds
Author(s) -
Aspin Sam,
Goutierre AnneSophie,
Larini Paolo,
Jazzar Rodolphe,
Baudoin Olivier
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206237
Subject(s) - alkyl , aryl , palladium , chemistry , catalysis , primary (astronomy) , combinatorial chemistry , medicinal chemistry , organic chemistry , stereochemistry , physics , astronomy
Remote control : The title reaction for β–ζ arylation of α‐amino esters with aryl bromides is described. This reaction, which occurs selectively at the terminal position of linear alkyl chains, gives rise to synthetically useful (hetero)arylalanines and homologues after debenzylation (see scheme).