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Cover Picture: Convergent Asymmetric Synthesis of (+)‐Aureothin Employing an Oxygenase‐Mediated Resolution Step (Angew. Chem. Int. Ed. 38/2012)
Author(s) -
Henrot Matthias,
Richter Martin E. A.,
Maddaluno Jacques,
Hertweck Christian,
De Paolis Michaël
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206228
Subject(s) - cover (algebra) , stereochemistry , courtesy , chemistry , convergence (economics) , monooxygenase , cytochrome p450 , philosophy , organic chemistry , engineering , enzyme , mechanical engineering , linguistics , economics , economic growth
Maximized convergence is the key in the assembly of the carbon backbone of the densely functionalized natural product (+)‐aureothin, as C. Hertweck and M. De Paolis et al. report in their Communication on page 9587 ff. The final step in the synthesis is the regiodivergent parallel kinetic resolution of the racemic precursor through in vivo treatment with a cytochrome P450 monooxygenase. (Background photography courtesy of Nico Überschaar; the authors also thank Martin E. A. Richter and Jonathan Rangapanaiken for their contribution to the cover picture.)