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Access to Sultams by Rhodium(III)‐Catalyzed Directed CH Activation
Author(s) -
Pham Manh V.,
Ye Baihua,
Cramer Nicolai
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206191
Subject(s) - rhodium , catalysis , sulfonamide , chemistry , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry
Director's cut : The pharmaceutically relevant sulfonamide group is shown to be a competent directing group for [Cp*Rh(OAc) 2 ]‐catalyzed CH functionalizations. Reactions of the cyclometalated intermediate with internal alkynes provide access to a wide range of sultam derivatives. The reaction is high yielding and works best under aerobic conditions with catalytic amounts of CuOAc as an oxidation mediator. Cp*=C 5 Me 5 .
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