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Synthesis of Five‐ and Six‐Membered Benzocyclic Ketones through Intramolecular Alkene Hydroacylation Catalyzed by Nickel(0)/N‐Heterocyclic Carbenes
Author(s) -
Hoshimoto Yoichi,
Hayashi Yukari,
Suzuki Haruka,
Ohashi Masato,
Ogoshi Sensuke
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206186
Subject(s) - hydroacylation , decarbonylation , alkene , intramolecular force , heteroatom , chemistry , catalysis , combinatorial chemistry , stereochemistry , organic chemistry , aldehyde , ring (chemistry)
Getting some closure : Mechanistic studies supported the participation of an oxanickelacycle complex in the hydroacylation step of the title reaction, which proceeds without decarbonylation even in the absence of well‐known chelation assistance by heteroatoms.