Premium
Eggshell‐Inspired Biomineralization Generates Vaccines that Do Not Require Refrigeration
Author(s) -
Wang Guangchuan,
Li Xiaofeng,
Mo Lijuan,
Song Zhiyong,
Chen Wei,
Deng Yongqiang,
Zhao Hui,
Qin Ede,
Qin Chengfeng,
Tang Ruikang
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206154
Subject(s) - biomineralization , thermostability , refrigeration , eggshell , vitrification , materials science , nanotechnology , chemical engineering , chemistry , biology , ecology , engineering , biochemistry , physics , mechanical engineering , nuclear physics , enzyme
We're not gonna bake it : In situ biomineralization creates an egg‐like shell on vaccine particles to improve their thermostability. Different from the bare vaccine (squares), the biomineralized vaccine (red circles) can be stored at ambient temperature without refrigeration for up to a week and retain biological activity both in vitro (see graph), as well as in a mouse model.