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Cover Picture: CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals (Angew. Chem. Int. Ed. 36/2012)
Author(s) -
Yamaguchi Junichiro,
Yamaguchi Atsushi D.,
Itami Kenichiro
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206131
Subject(s) - chemistry , combinatorial chemistry , total synthesis , bioinorganic chemistry , stereochemistry , nanotechnology , materials science
The functionalization of CH bonds has become an enabling tool in the synthesis of pharmaceutically relevant compounds and biologically active natural products. J. Yamaguchi, A. D. Yamaguchi, and K. Itami show in their Review on page 8960 ff. how it allows the summit (target compounds) to be reached in a most straightforward way. A series of studies not only streamlined the state‐of‐the‐art synthesis of useful molecular entities, but also changed the way chemists plan and execute chemical syntheses.