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In Vivo Fluorescence Imaging with Ag 2 S Quantum Dots in the Second Near‐Infrared Region
Author(s) -
Hong Guosong,
Robinson Joshua T.,
Zhang Yejun,
Diao Shuo,
Antaris Alexander L.,
Wang Qiangbin,
Dai Hongjie
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206059
Subject(s) - quantum dot , in vivo , fluorescence , infrared , nanotechnology , materials science , chemistry , physics , optics , biology , microbiology and biotechnology
Hits the dot : Ag 2 S quantum dots (QDs) with bright near‐infrared‐II fluorescence emission (around 1200 nm) and six‐arm branched PEG surface coating (see scheme) were synthesized for in vivo small‐animal imaging. The 6PEG‐Ag 2 S QDs afforded a tumor uptake of approximately 10 % injected dose/gram, owing to a long circulation half‐life of approximately 4 h. Clearance of the injected 6PEG‐Ag 2 S QDs occurs mainly through the biliary pathway in mice.