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Broad‐Spectrum Antimicrobial and Biofilm‐Disrupting Hydrogels: Stereocomplex‐Driven Supramolecular Assemblies
Author(s) -
Li Yan,
Fukushima Kazuki,
Coady Daniel J.,
Engler Amanda C.,
Liu Shaoqiong,
Huang Yuan,
Cho John S.,
Guo Yi,
Miller Lloyd S.,
Tan Jeremy P. K.,
Ee Pui Lai Rachel,
Fan Weimin,
Yang Yi Yan,
Hedrick James L.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206053
Subject(s) - self healing hydrogels , biofilm , antimicrobial , broad spectrum , biocompatibility , nanotechnology , multiple drug resistance , materials science , cytotoxicity , chemistry , combinatorial chemistry , in vitro , antibiotics , polymer chemistry , bacteria , organic chemistry , biology , biochemistry , metallurgy , genetics
Fighting the resistance : Biodegradable and injectable/moldable hydrogels with hierarchical nanostructures (see picture) were made with broad‐spectrum antimicrobial activities and biofilm‐disruption capability. They demonstrate no cytotoxicity in vitro, and show excellent skin biocompatibility in animals. These hydrogels have great potential for clinical use in prevention and treatment of various multidrug‐resistant infections.