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Acyclic Cucurbit[ n ]uril‐Type Molecular Containers Bind Neuromuscular Blocking Agents In Vitro and Reverse Neuromuscular Block In Vivo
Author(s) -
Ma Da,
Zhang Ben,
Hoffmann Ulrike,
Sundrup Martina Grosse,
Eikermann Matthias,
Isaacs Lyle
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201206031
Subject(s) - rocuronium , in vivo , block (permutation group theory) , blocking (statistics) , neuromuscular blocking agents , in vitro , chemistry , receptor , stereochemistry , biochemistry , pharmacology , biology , medicine , anesthesia , computer science , mathematics , genetics , computer network , geometry , propofol
Be My Guest : Two acyclic cucurbit[ n ]uril‐type receptors that carry SO 3 − ‐groups bind tightly to several commonly used neuromuscular blocking agents, such as rocuronium, in aqueous solution as revealed by direct and competitive UV/Vis binding assays. One of these containers functions as a potent reversal agent for rocuronium‐induced neuromuscular block in rats.