Acyclic Cucurbit[ n ]uril‐Type Molecular Containers Bind Neuromuscular Blocking Agents In Vitro and Reverse Neuromuscular Block In Vivo | Zendy

Ma Da | Zendy; Zhang Ben | Zendy; Hoffmann Ulrike | Zendy; Sundrup Martina Grosse | Zendy; Eikermann Matthias | Zendy; Isaacs Lyle | Zendy

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Acyclic Cucurbit[ n ]uril‐Type Molecular Containers Bind Neuromuscular Blocking Agents In Vitro and Reverse Neuromuscular Block In Vivo

Author(s) -

Ma Da,

Zhang Ben,

Hoffmann Ulrike,

Sundrup Martina Grosse,

Eikermann Matthias,

Isaacs Lyle

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201206031

Subject(s) - rocuronium , in vivo , block (permutation group theory) , blocking (statistics) , neuromuscular blocking agents , in vitro , chemistry , receptor , stereochemistry , biochemistry , pharmacology , biology , medicine , anesthesia , computer science , mathematics , genetics , computer network , geometry , propofol

Be My Guest : Two acyclic cucurbit[ n ]uril‐type receptors that carry SO 3 − ‐groups bind tightly to several commonly used neuromuscular blocking agents, such as rocuronium, in aqueous solution as revealed by direct and competitive UV/Vis binding assays. One of these containers functions as a potent reversal agent for rocuronium‐induced neuromuscular block in rats.

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