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Direct Pd‐Catalyzed Cross‐Coupling of Functionalized Organoaluminum Reagents
Author(s) -
Groll Klaus,
Blümke Tobias D.,
Unsinn Andreas,
Haas Diana,
Knochel Paul
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205987
Subject(s) - aryl , reagent , phosphine , catalysis , chemistry , tris , nitro , solvent , medicinal chemistry , coupling reaction , coupling (piping) , combinatorial chemistry , organic chemistry , polymer chemistry , materials science , biochemistry , alkyl , metallurgy
A handsome couple : Through the use of the simple Pd catalyst [Pd(tmpp) 2 Cl 2 ] (tmpp=tris(2,4,6‐trimethoxyphenyl)phosphine) and THF/DMF as solvent, various aryl‐, heteroaryl‐, benzyl‐ and alkylaluminum reagents can be readily cross‐coupled with aryl or heteroaryl iodides, bromides, and nonaflates, and in special cases even with chlorides and triflates. This cross‐coupling tolerates free NH 2 groups, aldehydes, ketones, esters, and nitro functions.