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High Antitumor Activity of Highly Resistant Salan–Titanium(IV) Complexes in Nanoparticles: An Identified Active Species
Author(s) -
Meker Sigalit,
MargulisGoshen Katrin,
Weiss Ester,
Magdassi Shlomo,
Tshuva Edit Y.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205973
Subject(s) - cytotoxicity , biological activity , hydrolysis , nanoparticle , chemistry , metabolic activity , peripheral blood mononuclear cell , titanium , function (biology) , combinatorial chemistry , nanotechnology , materials science , biochemistry , organic chemistry , biology , in vitro , physiology , microbiology and biotechnology
A nanoformulated trinuclear hydrolysis product of a bis(alkoxo) salan–Ti IV complex shows high antitumor activity (see picture), which identifies it as an active species in cells. Additional highly stable mononuclear derivatives also show high activity, when formulated into nanoparticles, thus evincing that biologically friendly Ti IV can provide high cytotoxicity with controlled biological function.