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Nickel‐Catalyzed Kumada Reaction of Tosylalkanes with Grignard Reagents to Produce Alkenes and Modified Arylketones
Author(s) -
Wu JiCheng,
Gong LuBing,
Xia Yuanzhi,
Song RenJie,
Xie YeXiang,
Li JinHeng
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205969
Subject(s) - reagent , alkene , electrophile , catalysis , chemistry , coupling reaction , nickel , alkyl , grignard reagent , organic chemistry , combinatorial chemistry
Open a new door : The first example of alkene synthesis from alkyl electrophiles with Grignard reagents using the Kumada cross‐coupling reaction strategy is reported. This method opens a new door for the Kumada cross‐coupling reaction, allowing alkenes to be prepared from the reaction of tosylalkanes with Grignard reagents.