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A Functional‐Group‐Tolerant Catalytic trans Hydrogenation of Alkynes
Author(s) -
Radkowski Karin,
Sundararaju Basker,
Fürstner Alois
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205946
Subject(s) - catalysis , cationic polymerization , template , functional group , substrate (aquarium) , chemistry , combinatorial chemistry , catalytic hydrogenation , stereochemistry , medicinal chemistry , organic chemistry , nanotechnology , materials science , biology , ecology , polymer
Against the rules : During the hundred years following Sabatier's groundbreaking work on catalytic hydrogenation, syn delivery of the H atoms to the π system of a substrate remained the governing stereochemical rule. An exception has now be found with the use of cationic [Cp*Ru] templates, which accounts for the first practical, functional‐group‐tolerant, broadly applicable and highly E ‐selective semihydrogenation method for alkynes (see scheme).