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Organocatalytic Amidation and Esterification of Aldehydes with Activating Reagents by a Cross‐Coupling Strategy
Author(s) -
Tan Bin,
Toda Narihiro,
Barbas Carlos F.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205921
Subject(s) - reagent , chemistry , alcohol , organic chemistry , combinatorial chemistry , coupling (piping) , coupling reaction , organocatalysis , catalysis , enantioselective synthesis , materials science , metallurgy
Formation on demand : An organocatalytic cross‐coupling reaction of aldehydes with N ‐hydroxyimides, hexafluoroisopropyl alcohol, and sulfonimides has been developed. The resulting active intermediates can be directly converted into amides or esters in one pot. This simple method makes use of readily available starting materials, and the newly discovered activating reagents should find broad application in the synthesis of amides and esters.