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Highly Efficient Stereoselective Catalytic C(sp 3 )H Insertions with Donor Rhodium Carbenoids Generated from Cyclopropenes
Author(s) -
Archambeau Alexis,
Miege Frédéric,
Meyer Christophe,
Cossy Janine
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205913
Subject(s) - rhodium , stereoselectivity , intramolecular force , reactivity (psychology) , chemistry , catalysis , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , medicine , alternative medicine , pathology
Rings of five and six : Donor alkenyl rhodium carbenoids generated from 3,3‐dimethylcyclopropenylcarbinols exhibit high reactivity in intramolecular CH insertions. The reactions proceed under remarkably mild conditions, tolerate the presence of the free hydroxy group, and afford an efficient and stereoselective access to a variety of functionalized carbocycles and oxygen heterocycles.