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Enantioselective Copper(I)‐Catalyzed Borylative Aldol Cyclizations of Enone Diones
Author(s) -
Burns Alan R.,
Solana González Jorge,
Lam Hon Wai
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205899
Subject(s) - desymmetrization , enone , enantioselective synthesis , aldol reaction , bicyclic molecule , chemistry , catalysis , aldol condensation , stereochemistry , organic chemistry
Piña colato? In the presence of a chiral Cu I /bisphosphine complex and B 2 (pin) 2 , enone diones undergo diastereo‐ and enantioselective desymmetrization to deliver highly functionalized bicyclic products. The products can be used as substrates in additional transformations. pin=pinacolato, Cy=cyclohexyl.