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Copper‐Mediated Difluoromethylation of (Hetero)aryl Iodides and β‐Styryl Halides with Tributyl(difluoromethyl)stannane
Author(s) -
Prakash G. K. Surya,
Ganesh Somesh K.,
Jones JohnPaul,
Kulkarni Aditya,
Masood Kamil,
Swabeck Joseph K.,
Olah George A.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205850
Subject(s) - stannane , aryl , halide , reagent , chemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , alkyl
Owing to their unique properties , molecules containing the difluoromethyl group (CF 2 H) are of great interest. Tributyl(difluoromethyl)stannane has now been used for the selective and efficient direct ipso difluoromethylation of aryl iodides, heterocyclic iodides, and β‐styryl halides (see scheme). The straightforward preparation of the difluoromethylating reagent makes this approach particularly valuable.