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Organocatalytic Activation of Polycyclic Aromatic Compounds for Asymmetric Diels–Alder Reactions
Author(s) -
Jiang Hao,
RodríguezEscrich Carles,
Johansen Tore Kiilerich,
Davis Rebecca L.,
Jørgensen Karl Anker
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205836
The anglerfish catalyst : The activation of anthracenes through aminocatalysis (see scheme) allows them to undergo [4+2] cycloadditions with concomitant breaking of the aromaticity at room temperature and low catalyst loadings. A highly enantioselective Diels–Alder reaction of anthracenes has been developed using nitroalkenes as dienophiles.