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Iron‐Facilitated Oxidative Dehydrogenative CO Bond Formation by Propargylic C sp 3 H Functionalization
Author(s) -
Wang Teng,
Zhou Wang,
Yin Hang,
Ma JunAn,
Jiao Ning
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205779
Subject(s) - surface modification , moiety , propargyl , chemistry , triple bond , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , catalysis , double bond
Hot couple : Propargyl azides were coupled with carboxylic acids by an iron‐catalyzed dehydrogenative CO bond formation (see scheme). This method enables propargylic C sp 3H functionalization under mild reaction conditions and also may involve the application of the azido moiety as an assisting group in CH activation.