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Pyrrole‐Imidazole Polyamides Distinguish Between Double‐Helical DNA and RNA
Author(s) -
Chenoweth David M.,
Meier Jordan L.,
Dervan Peter B.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205775
Subject(s) - minor groove , dna , duplex (building) , nucleic acid , imidazole , rna , polyamide , groove (engineering) , chemistry , pyrrole , stereochemistry , base pair , helix (gastropod) , crystallography , biochemistry , biology , polymer chemistry , materials science , organic chemistry , gene , metallurgy , ecology , snail
Groove specificity : Pyrrole‐imidazole polyamides are well‐known for their specific interactions with the minor groove of DNA (see scheme). However, polyamides do not show similar binding to duplex RNA, and a structural rationale for the molecular‐level discrimination of nucleic acid duplexes by minor‐groove‐binding ligands is presented.