Pd‐PEPPSI‐IPent Cl : A Highly Effective Catalyst for the Selective Cross‐Coupling of Secondary Organozinc Reagents | Zendy

Pompeo Matthew | Zendy; Froese Robert D. J. | Zendy; Hadei Niloufar | Zendy; Organ Michael G. | Zendy

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Pd‐PEPPSI‐IPent Cl : A Highly Effective Catalyst for the Selective Cross‐Coupling of Secondary Organozinc Reagents

Author(s) -

Pompeo Matthew,

Froese Robert D. J.,

Hadei Niloufar,

Organ Michael G.

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201205747

Subject(s) - reagent , catalysis , coupling (piping) , chemistry , combinatorial chemistry , materials science , organic chemistry , metallurgy

No migration? No problem! A series of new N‐heterocyclic carbene based Pd complexes has been created and evaluated in the Negishi cross‐coupling of aryl and heteroaryl chlorides, bromides, and triflates with a variety of secondary alkylzinc reagents (see scheme). The direct elimination product is nearly exclusively formed; in most examples there is no migratory insertion at all.

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