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Pd‐PEPPSI‐IPent Cl : A Highly Effective Catalyst for the Selective Cross‐Coupling of Secondary Organozinc Reagents
Author(s) -
Pompeo Matthew,
Froese Robert D. J.,
Hadei Niloufar,
Organ Michael G.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205747
Subject(s) - reagent , catalysis , coupling (piping) , chemistry , combinatorial chemistry , materials science , organic chemistry , metallurgy
No migration? No problem! A series of new N‐heterocyclic carbene based Pd complexes has been created and evaluated in the Negishi cross‐coupling of aryl and heteroaryl chlorides, bromides, and triflates with a variety of secondary alkylzinc reagents (see scheme). The direct elimination product is nearly exclusively formed; in most examples there is no migratory insertion at all.