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Rhodium‐Catalyzed Direct CH Amination of Benzamides with Aryl Azides: A Synthetic Route to Diarylamines
Author(s) -
Ryu Jaeyune,
Shin Kwangmin,
Park Sae Hume,
Kim Ji Young,
Chang Sukbok
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205723
Subject(s) - amination , rhodium , chemistry , aryl , catalysis , amine gas treating , combinatorial chemistry , functional group , reagent , intermolecular force , substrate (aquarium) , organic chemistry , medicinal chemistry , molecule , alkyl , oceanography , geology , polymer
No muss, no fuss : A rhodium‐catalyzed direct intermolecular CH amination of benzamides and ketoximes using aryl azides as the amine source has been developed. The reaction exhibits a broad substrate scope with excellent functional‐group tolerance, requires no external oxidants, releases N 2 as the only by‐product, and produces diarylamines in high yields.