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Cover Picture: Molecular Composition of Sub‐stoichiometrically Labeled α‐Synuclein Oligomers Determined by Single‐Molecule Photobleaching (Angew. Chem. Int. Ed. 35/2012)
Author(s) -
Zijlstra Niels,
Blum Christian,
SegersNolten Ine M. J.,
Claessens Mireille M. A. E.,
Subramaniam Vinod
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205691
Subject(s) - photobleaching , monomer , stoichiometry , chemistry , cover (algebra) , supramolecular chemistry , molecule , biophysics , crystallography , polymer , biology , fluorescence , organic chemistry , physics , optics , mechanical engineering , engineering
In amyloid diseases , monomeric proteins self‐assemble into supramolecular aggregates. In their Communication on page 8821 ff. V. Subramaniam et al. describe a new method that combines single‐molecule photobleaching approaches with sub‐stoichiometric labeling with fluorophores to determine the molecular composition of these large protein aggregates. The cover picture shows the aggregation of combinations of labeled and unlabeled monomers and the subsequent photobleaching analysis of single aggregates.