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Continuous Stochastic Detection of Amino Acid Enantiomers with a Protein Nanopore
Author(s) -
Boersma Arnold J.,
Bayley Hagan
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205687
Subject(s) - nanopore , enantiomer , amino acid , computer science , chemistry , resolution (logic) , combinatorial chemistry , nanotechnology , biochemistry , stereochemistry , artificial intelligence , materials science
A stochastic sensing method : Discrimination between enantiomeric amino acids is achieved when the amino acids bind to a Cu II complex within a protein nanopore sensor, which provides a chiral environment. The potential of the method is demonstrated by real‐time observation of the increase in enantiomeric excess during an enzymatic kinetic resolution.