A Nonmetal Approach to α‐Heterofunctionalized Carbonyl Derivatives by Formal Reductive XH Insertion | Zendy

Miller Eric J. | Zendy; Zhao Wei | Zendy; Herr Jonathan D. | Zendy; Radosevich Alexander T. | Zendy

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A Nonmetal Approach to α‐Heterofunctionalized Carbonyl Derivatives by Formal Reductive XH Insertion

Author(s) -

Miller Eric J.,

Zhao Wei,

Herr Jonathan D.,

Radosevich Alexander T.

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201205604

Subject(s) - nonmetal , diazo , scheme (mathematics) , chemistry , decomposition , combinatorial chemistry , computer science , medicinal chemistry , organic chemistry , mathematics , mathematical analysis , metal

Keeping it organic : A direct synthesis of α‐alkoxy and α‐amino ester derivatives by direct reductive coupling of widely available, stable α‐keto esters and protic pronucleophiles is described (see scheme; X=OR, NR 2 ). The method serves as a convenient nonmetal alternative to XH insertion by diazo decomposition.

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