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Chemical Synthesis of a Heparan Sulfate Glycopeptide: Syndecan‐1
Author(s) -
Yang Bo,
Yoshida Keisuke,
Yin Zhaojun,
Dai Hang,
Kavunja Herbert,
ElDakdouki Mohammad H.,
Sungsuwan Suttipun,
Dulaney Steven B.,
Huang Xuefei
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205601
Subject(s) - library science , chemistry , computer science
Finishing first : The highly complex structure of the title compound (see picture) was assembled. The protective groups utilized, as well as the sequences for formation of the glycosyl linkages and protecting group removal are critical to the success of the synthesis. This first preparation of a heparan sulfate glycopeptide lays the foundation for accessing other members of this class of molecules.