Palladium‐Catalyzed Coupling of  ortho ‐Alkynylanilines with Terminal Alkynes Under Aerobic Conditions: Efficient Synthesis of 2,3‐Disubstituted 3‐Alkynylindoles | Zendy

Yao Bo | Zendy; Wang Qian | Zendy; Zhu Jieping | Zendy

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Palladium‐Catalyzed Coupling of ortho ‐Alkynylanilines with Terminal Alkynes Under Aerobic Conditions: Efficient Synthesis of 2,3‐Disubstituted 3‐Alkynylindoles

Author(s) -

Yao Bo,

Wang Qian,

Zhu Jieping

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201205596

Subject(s) - catalysis , palladium , nucleophile , terminal (telecommunication) , coupling (piping) , triple bond , medicinal chemistry , chemistry , combinatorial chemistry , polymer chemistry , organic chemistry , double bond , computer science , materials science , telecommunications , metallurgy

Two nucleophiles, one triple bond : Under aerobic conditions, palladium‐catalyzed direct coupling of o ‐alkynylanilines and terminal alkynes took place smoothly to afford the 2,3‐disubstituted 3‐alkynylindoles 3 in good to excellent yields. The intermediate A was characterized and a retro‐aminopalladation of B was observed for the first time.

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