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Palladium‐Catalyzed Coupling of ortho ‐Alkynylanilines with Terminal Alkynes Under Aerobic Conditions: Efficient Synthesis of 2,3‐Disubstituted 3‐Alkynylindoles
Author(s) -
Yao Bo,
Wang Qian,
Zhu Jieping
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205596
Subject(s) - catalysis , palladium , nucleophile , terminal (telecommunication) , coupling (piping) , triple bond , medicinal chemistry , chemistry , combinatorial chemistry , polymer chemistry , organic chemistry , double bond , computer science , materials science , telecommunications , metallurgy
Two nucleophiles, one triple bond : Under aerobic conditions, palladium‐catalyzed direct coupling of o ‐alkynylanilines and terminal alkynes took place smoothly to afford the 2,3‐disubstituted 3‐alkynylindoles 3 in good to excellent yields. The intermediate A was characterized and a retro‐aminopalladation of B was observed for the first time.