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The ortho and meta Magnesiation of Functionalized Anilines and Amino‐Substituted Pyridines and Pyrazines at Room Temperature
Author(s) -
Monzón Gabriel,
Tirotta Ilaria,
Knochel Paul
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205465
Subject(s) - aminopyridines , chemistry , combinatorial chemistry , medicinal chemistry , organic chemistry
A practical ortho , meta , (or even ortho , ortho ′) magnesiation of trifluoroacetamides of anilines, aminopyridines, and aminopyrazines at room temperature was performed with TMPMgCl⋅LiCl or TMP 2 Mg⋅2 LiCl. These magnesiations are compatible with several carbonyl functionalities and allow access to polysubstituted anilides in satisfactory yields.