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One‐Pot Gold‐Catalyzed Synthesis of Azepino[1,2‐ a ]indoles
Author(s) -
Cera Gianpiero,
Piscitelli Stefano,
Chiarucci Michel,
Fabrizi Giancarlo,
Goggiamani Antonella,
Ramón Rubén S.,
Nolan Steven P.,
Bandini Marco
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205463
Subject(s) - chemoselectivity , carbene , catalysis , combinatorial chemistry , chemistry , stoichiometry , reaction conditions , organic chemistry
Indoles from scratch : A gold(I)/N‐heterocyclic carbene complex (IPr=1,3‐di(isopropylphenyl)imidazol‐2‐ylidene) was found to be particularly effective as a catalyst, enabling the one‐pot synthesis of tricyclic azepinoindoles by an unprecedented cascade reaction. Readily available substrates, high chemoselectivity, good yields, and water as the only stoichiometric by‐product are some of the main advantages of this method.