A Simple Synthesis of Sugar Nucleoside Diphosphates by Chemical Coupling in Water | Zendy

Tanaka Hidenori | Zendy; Yoshimura Yayoi | Zendy; Jørgensen Malene R. | Zendy; CuestaSeijo Jose A. | Zendy; Hindsgaul Ole | Zendy

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A Simple Synthesis of Sugar Nucleoside Diphosphates by Chemical Coupling in Water

Author(s) -

Tanaka Hidenori,

Yoshimura Yayoi,

Jørgensen Malene R.,

CuestaSeijo Jose A.,

Hindsgaul Ole

Publication year - 2012

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201205433

Subject(s) - sugar , nucleotide , nucleoside , simple (philosophy) , chemistry , nucleobase , computer science , reagent , glycosyltransferase , biochemistry , combinatorial chemistry , organic chemistry , dna , philosophy , gene , epistemology

Sugar nucleotides made easy : The new reagent “ImIm”, which is formed in situ in water, is shown to activate nucleoside 5′‐phosphates to their imidazolides, these can subsequently couple with sugar‐1‐phosphates; the whole procedure takes place in water. This truly simple method yields a crude product mixture that can be used directly as a source of donors for glycosyltransferase‐mediated oligsaccharide synthesis. In the scheme, B stands for the nucleobases U, A, or G.

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