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Tri‐G‐Quadruplex: Controlled Assembly of a G‐Quadruplex Structure from Three G‐Rich Strands
Author(s) -
Zhou Jun,
Bourdoncle Anne,
Rosu Frédéric,
Gabelica Valérie,
Mergny JeanLouis
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205390
Subject(s) - g quadruplex , duplex (building) , chemistry , dna , computer science , information retrieval , computational biology , biochemistry , biology
In my (DNA) dreams : A tri‐G‐quadruplex was constructed from three strands (T1–T3) of DNA using duplex formation to guide the G‐rich tracts into close proximity with the addition of Li + ions (see scheme). The defined G‐quadruplex structure was formed upon addition of Na + ions and characterized by gel electrophoresis and spectroscopy.