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Reciprocal Cross Talk between Fatty Acid and Antibiotic Biosynthesis in a Nematode Symbiont
Author(s) -
Brachmann Alexander O.,
Reimer Daniela,
Lorenzen Wolfram,
Augusto Alonso Eduardo,
Kopp Yannick,
Piel Jörn,
Bode Helge B.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205384
Subject(s) - biosynthesis , reciprocal , fatty acid , biochemistry , fatty acid synthesis , identification (biology) , chemistry , biology , gene , botany , philosophy , linguistics
Don't play the second fiddle! The identification of different arrangements of branched‐chain keto acid dehydrogenases usually involved in the biosynthesis of cellular building blocks is demonstrated (see scheme). Direct cross talk between secondary metabolism ketosynthases (KS) and fatty acid biosynthesis is shown and the biosynthesis of odd‐numbered iso‐fatty acids is found to be connected to the production of pristinamycin II a .