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A Common Diaryl Ether Intermediate for the Gram‐Scale Synthesis of Oxazine and Xanthene Fluorophores
Author(s) -
Anzalone Andrew V.,
Wang Tracy Y.,
Chen Zhixing,
Cornish Virginia W.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205369
Subject(s) - xanthene , computer science , key (lock) , scale (ratio) , combinatorial chemistry , chemistry , world wide web , nanotechnology , computer security , organic chemistry , materials science , physics , quantum mechanics
Common ground : Copper‐catalyzed coupling reactions can be used for the high‐yielding preparation of widely used oxazine and xanthene fluorophores from a common diaryl ether intermediate on a gram‐scale (see scheme). This general approach may facilitate the future development of novel fluorophores and probes with unique properties.