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Hydrogen Bonds Guide the Short‐Lived 5′‐Deoxyadenosyl Radical to the Place of Action
Author(s) -
Buckel Wolfgang,
Friedrich Peter,
Golding Bernard T.
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205299
Subject(s) - chemistry , moiety , homolysis , hydrogen bond , pseudorotation , radical , photochemistry , ribose , stereochemistry , organic chemistry , molecule , enzyme
Radical chaperone : Recent research reveals how the 5′‐deoxyadenosyl radical (see structure) is generated by homolysis of the CoC σ‐bond of enzyme‐bound coenzyme B 12 and how it is guided to the substrate through pseudorotation of the ribose moiety and hydrogen‐bonding interactions.