Premium
Synthesis of Azepine Derivatives by Rhodium‐Catalyzed Tandem 2,3‐Rearrangement/Heterocyclization
Author(s) -
Nakamura Itaru,
Okamoto Masashi,
Sato Yoshinori,
Terada Masahiro
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205285
Subject(s) - azepine , tandem , rhodium , chemistry , catalysis , combinatorial chemistry , catalytic cycle , stereochemistry , organic chemistry , materials science , composite material
Easy to N‐cycle : The efficient synthesis of azepine derivatives was achieved by Rh‐catalyzed tandem 2,3‐rearrangement involving the heterocyclization of N‐ allenylnitrone intermediates (see scheme; cod=1,5‐cyclooctadiene, tppms=sodium diphenylphosphinobenzene‐3‐sulfonate).