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Gallium(III)‐Catalyzed Three‐Component (4+3) Cycloaddition Reactions
Author(s) -
Han Xinping,
Li Hui,
Hughes Russell P.,
Wu Jimmy
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205238
Direct approach to indoles : The title reaction generates cyclohepta[ b ]indole derivatives in a single step at room temperature (see scheme). Exclusion of air or moisture is not required. DFT calculations support a stepwise cyclization event, and the versatility of the method is demonstrated by providing quick access to a library of cyclohepta[ b ]indole analogues.