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S N 2′ Alkylation of Cyclopropanols via Homoenolates
Author(s) -
Das Pragna Pratic,
Belmore Ken,
Cha Jin Kun
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205190
Subject(s) - enantiopure drug , alkylation , electrophile , sn2 reaction , reagent , information retrieval , reactivity (psychology) , computer science , combinatorial chemistry , chemistry , stereochemistry , organic chemistry , medicine , enantioselective synthesis , catalysis , alternative medicine , pathology
Reining in reactivity : Stereoselective S N 2′ alkylation of cyclopropanols has been devised under the control of mixed zinc/copper reagents. This method provides convenient access to enantiopure keto homoenolates which react with electrophiles (El + ) to form CC bonds. M=metal.