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Inside Cover: Polyspermine Imidazole‐4,5‐imine, a Chemically Dynamic and Biologically Responsive Carrier System for Intracellular Delivery of siRNA (Angew. Chem. Int. Ed. 32/2012)
Author(s) -
Duan Shiyue,
Yuan Weien,
Wu Fei,
Jin Tuo
Publication year - 2012
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201205175
Subject(s) - imidazole , imine , cover (algebra) , intracellular , chemistry , nanotechnology , drug delivery , combinatorial chemistry , stereochemistry , biochemistry , materials science , organic chemistry , engineering , catalysis , mechanical engineering
Unlocking the endosome allows the release of siRNAs into the cytoplasm following the cellular uptake of nanoparticles made up of siRNAs and polyspermine imidazole‐4,5‐imine. In their Communication on page 7938 ff. , T. Jin and co‐workers show that a polymer of spermine with a pH‐sensitive linkage degrades, upon entry into the endosome, into spermine and a nontoxic metabolite. Assays in cells and mice showed effective gene silencing by the polymer‐packaged siRNAs without cytotoxicity.